Use RhoDesign RNA Inverse Folding

Overview

RhoDesign is a deep learning platform for the generative design of RNA sequences informed by 3D structural data. By leveraging a combination of geometric vector perceptrons (GVPs) to encode RNA tertiary structures and transformer architectures to process structural and sequence relationships, it generates RNA sequences predicted to match specific structural backbones. The platform has been successfully applied to design fluorescent RNA aptamers, which demonstrated structural fidelity and novel sequence diversity while maintaining functionality. Benchmark evaluations highlighted its superior performance compared to other models, making it a powerful tool for resource-efficient and targeted RNA design.

Neurosnap Overview

The RhoDesign RNA Inverse Folding online webserver allows anybody with a Neurosnap account to run and access RhoDesign RNA Inverse Folding, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong terms of service and privacy policy.