Use CryoSAMU
Official Neurosnap webserver for accessing CryoSAMU online.
Overview
Enhancing cryogenic electron microscopy (cryo-EM) 3D density maps at intermediate resolution (4-8 Ã…) is crucial in protein structure determination. CryoSAMU is a novel method designed to enhance these maps using structure-aware multimodal U-Nets. It integrates 3D map features with structural embeddings from the ESM-IF1 protein language model. By training on a curated dataset of intermediate-resolution maps, CryoSAMU improves map quality, shows competitive performance against state-of-the-art methods, and achieves significantly faster processing speeds.
Neurosnap Overview
The CryoSAMU online webserver allows anybody with a Neurosnap account to run and access CryoSAMU, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong terms of service and privacy policy.
View PaperFeatures
- First multimodal network integrating structural information into a 3D U-Net for cryo-EM map enhancement.
- Uses cross-attention mechanisms to fuse 3D map features with structural embeddings from ESM-IF1.
- Employs a self-attention-based post-processing for structural embeddings to preserve chain and residue relationships.
- Optimized for intermediate-resolution (4-8 Ã…) cryo-EM maps.
- Demonstrates competitive performance with significantly faster processing speeds (4.2x to 16.7x faster than other methods).
- Improves protein structure modeling from density maps, increasing residue coverage and sequence match.
Statistics
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API Request
Access CryoSAMU using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.
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