Use CryoAtom Cryo-EM Model Builder

Official Neurosnap webserver for accessing CryoAtom Cryo-EM Model Builder online.

Overview

CryoAtom is an approach for de novo model building from cryogenic electron microscopy (cryo-EM) density maps. It leverages advancements from AlphaFold2, replacing global attention with a local attention mechanism enhanced by a novel 3D rotary position embedding. This allows CryoAtom to produce more complete atomic models, lower the required map resolution, and significantly accelerate the modeling process compared to existing methods.

Neurosnap Overview

The CryoAtom Cryo-EM Model Builder online webserver allows anybody with a Neurosnap account to run and access CryoAtom Cryo-EM Model Builder, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong terms of service and privacy policy.

View Paper

Features

  • Leverages a local attention mechanism and 3D rotary position embedding for improved accuracy.
  • Produces more complete models and reduces the resolution requirement for cryo-EM maps.
  • Accelerates the modeling process, enabling the construction of large, 100+ protein complexes in hours.
  • Accurately distinguishes between paralog sequences, even in noisy map regions.
  • Detects and models previously uncharacterized proteins and structural extensions.
  • Captures minor conformational changes within mega-Dalton complexes.

Statistics

Neurosnap periodically calculates runtime statistics based on job execution data. These estimates provide a general guideline for how long your job may take, but actual runtimes can vary significantly depending on factors like input size or settings used.

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API Request

Access CryoAtom Cryo-EM Model Builder using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.

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Job Note

Provide a name or description for your job to help you organize and track its results. This input is solely for organizational purposes and does not impact the outcome of the job.

Configuration & Options

Service Inputs

Allowed Types: map or mrc
Upload the cryo-EM density map in .map or .mrc format.

Provide the input protein sequences to be modeled into the density map. There is no need to provide duplicate sequences.

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