BioPhi
AI-driven antibody humanization + humanness scoring from natural repertoire data.
Overview
BioPhi combines Sapiens (deep learning antibody humanization) with OASis (9-mer humanness evaluation from 231 human repertoires) to redesign non-human antibodies while quantifying immunogenicity risk.
Run BioPhi on Neurosnap
The BioPhi online webserver allows anybody with a Neurosnap account to run and access BioPhi, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong Terms of Use and Privacy Policy.
Features
- Accepts antibodies (VH:VL), nanobodies (single domain), and scFvs (VH:VL domains) as input.
- Generates humanized sequence candidates and summary reports suitable for downstream filtering.
- Exports tool outputs (e.g., FASTA/Excel) for easy review and comparison.
Statistics
Neurosnap periodically calculates runtime statistics based on job execution data. These estimates provide a general guideline for how long your job may take, but actual runtimes can vary significantly depending on factors like input size or settings used.
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API Request
Access BioPhi using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.
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Citations
Please cite the original work when using BioPhi in publications or research outputs.
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Prihoda D, Maamary J, Waight A, Juan V, Fayadat-Dilman L, Svozil D, Bitton DA. BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning. MAbs. 2022 Jan-Dec;14(1):2020203. doi: 10.1080/19420862.2021.2020203. PMID: 35133949; PMCID: PMC8837241. |
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Neurosnap Inc. (2022). Neurosnap: An online platform for computational biology and chemistry. Available at: https://neurosnap.ai/ |