Use AlphaBind Antibody-Antigen Affinity Prediction
Official Neurosnap webserver for accessing AlphaBind Antibody-Antigen Affinity Prediction online.
Overview
AlphaBind fine-tunes its public pretrained affinity model on target-specific antibody-antigen measurements, then ranks submitted antibody candidates against the same antigen. This supervised workflow combines ESM-2nv protein language model embeddings with an affinity regression network and avoids presenting the public checkpoint as a generally reliable zero-shot affinity predictor.
Neurosnap Overview
The AlphaBind Antibody-Antigen Affinity Prediction online webserver allows anybody with a Neurosnap account to run and access AlphaBind Antibody-Antigen Affinity Prediction, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong Terms of Use and Privacy Policy.
Features
- Fine-tunes the published AlphaBind checkpoint on uploaded target-specific affinity or assay measurements.
- Scores up to 64 antibody candidates against the same protein antigen after supervised fine-tuning.
- Supports log10(KD in nM) labels or custom lower-is-better assay scores without conflating the two scales.
- Returns ranked predictions, training metrics, and the resulting fine-tuned AlphaBind model.
Statistics
Neurosnap periodically calculates runtime statistics based on job execution data. These estimates provide a general guideline for how long your job may take, but actual runtimes can vary significantly depending on factors like input size or settings used.
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API Request
Access AlphaBind Antibody-Antigen Affinity Prediction using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.
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Citations
Please cite the original work when using AlphaBind Antibody-Antigen Affinity Prediction in publications or research outputs.
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Agarwal AA, Harrang J, Noble D, McGowan KL, Lange AW, Engelhart E, et al. AlphaBind, a domain-specific model to predict and optimize antibody-antigen binding affinity. mAbs. 2025;17(1):2534626. https://doi.org/10.1080/19420862.2025.2534626 |
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Neurosnap Inc. (2022). Neurosnap: An online platform for computational biology and chemistry. Available at: https://neurosnap.ai/ |
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