🧬 How to use ANARCII Online

Use ANARCII online for language-model-based antibody and TCR numbering at repertoire scale.

ANARCII is a next-generation immune receptor annotation framework that uses language-model-based sequence understanding to number and classify antibody and TCR domains at scale. Compared with older HMM-centered workflows, it is designed to be more robust on unusual, incomplete, or atypical sequences.

On Neurosnap, you submit batches of Input Sequences, choose a numbering Scheme, specify Sequence Type when known, and receive a repertoire-oriented summary table for fast annotation, filtering, and downstream curation.

How ANARCII Works

ANARCII couples antigen-receptor classification with standardized numbering across common schemes, but its main technical change is the use of a modern protein language model backbone rather than relying only on classical alignment heuristics. That improves throughput and expands support for harder cases such as atypical chains or partially complete inputs.

On Neurosnap, Scheme and Sequence Type make it easy to constrain annotation when the repertoire composition is already known or to leave the tool more exploratory when it is not. The output is structured around per-domain assignments, numbering, and chain labels so users can rapidly clean and organize large immune-receptor datasets.

What is Neurosnap?

Neurosnap is the leading platform for bioinformatics and computational science focused on expanding access to powerful modeling and simulation tools. Because many state-of-the-art machine learning systems remain complex to install, configure, and scale, Neurosnap offers a clean, browser-based workspace that removes the burden of infrastructure management, dependency conflicts, and command-line tooling.

Built for biologists, chemists, and cross-disciplinary scientists, the platform enables advanced computational workflows without requiring expertise in software engineering or cloud architecture. Researchers can launch analyses through an intuitive interface, connect programmatically through a comprehensive API, and rely on automated resource management to scale workloads efficiently. By taking care of the underlying compute and operational complexity, Neurosnap allows teams to devote their energy to scientific progress and faster iteration. Security and data protection remain foundational principles, with clear safeguards outlined in our Terms of Use and Privacy Policy to ensure your work stays protected.

Advancing Discovery with ANARCII on Neurosnap

Using ANARCII on Neurosnap could drastically accelerate large-scale immune-receptor numbering and classification from input sequences.

Study-fit inputs: ANARCII accepts large batches of receptor sequences, which makes it practical for repertoire-scale annotation rather than only single-sequence lookup.
Language-model backbone: The method is designed to be more tolerant of unusual or incomplete sequences than older purely alignment-driven approaches.
Protocol control: Researchers can tune Scheme and Sequence Type to narrow the annotation problem when prior biological context is available.
Readable evidence: The results page is centered on per-domain numbering and classification summaries, which makes downstream filtering and curation straightforward.
Faster iteration: Managed execution on Neurosnap removes infrastructure overhead so teams can focus on repertoire interpretation rather than local annotation pipelines.

How to Use ANARCII on Neurosnap

To harness the capabilities of ANARCII, researchers can follow this streamlined workflow within Neurosnap:

Access Neurosnap: Start by logging in to the Neurosnap website.
Select Tool: From the list of available tools, choose ANARCII.
Provide Inputs: Provide all the inputs specified within the submission panel and optionally configure the tool as desired.
Run Tool: Submit the ANARCII job and Neurosnap will execute it in the cloud, automatically notifying you as soon as your results are ready.
Review Output: Explore your results through rich visualizations, including figures, plots, and interactive views designed to help you analyze findings with clarity and confidence.

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