How to Use Immune Builder
Commercially Available Online Web Server
Use Immune Builder online for rapid antibody, nanobody, and T-cell receptor structure prediction from sequence.
Immune Builder is a specialized structure-prediction suite for immune proteins, combining AbodyBuilder2, NanoBodyBuilder2, and TCRBuilder2 in a single workflow. Instead of asking a general folding model to handle every immune architecture equally well, these models are tuned for antibodies, single-domain nanobodies, and alpha-beta TCRs, which makes them attractive for lead discovery, repertoire analysis, and therapeutic engineering.
On Neurosnap, researchers can submit paired Heavy Chain and Light Chain sequences for antibodies, a single Nanobody Sequence, or Alpha Chain plus Beta Chain for TCRs. The service accepts one immune construct at a time, which keeps the workflow focused on per-candidate structural review rather than generic batch folding.
The results are organized around geometry and uncertainty. An interactive structure view plus per-residue predicted error make it easy to see whether the framework is stable and which CDRs or chain interfaces deserve extra caution.
How Immune Builder Works
The ImmuneBuilder paper emphasizes fast, specialized prediction rather than a one-size-fits-all architecture. AbodyBuilder2, NanoBodyBuilder2, and TCRBuilder2 are trained for their respective immune-protein classes, and the pipeline finishes with OpenMM-based refinement to improve stereochemistry before the model is presented for inspection.
On Neurosnap, the input format mirrors experimental practice. Users provide only the sequences relevant to the immune format they care about, which makes the tool useful for antibody discovery teams that want a structural hypothesis without building a full general-purpose folding workflow around each candidate.
Researchers typically use the output for loop review, paratope positioning, and developability triage. The predicted-error trace is especially helpful for deciding whether a CDR conformation looks trustworthy enough for docking, humanization planning, or mutational design.
What is Neurosnap?
Neurosnap is the leading platform for bioinformatics and computational science focused on expanding access to powerful modeling and simulation tools. Because many state-of-the-art machine learning systems remain complex to install, configure, and scale, Neurosnap offers a clean, browser-based workspace that removes the burden of infrastructure management, dependency conflicts, and command-line tooling.
Built for biologists, chemists, and cross-disciplinary scientists, the platform enables advanced computational workflows without requiring expertise in software engineering or cloud architecture. Researchers can launch analyses through an intuitive interface, connect programmatically through a comprehensive API, and rely on automated resource management to scale workloads efficiently. By taking care of the underlying compute and operational complexity, Neurosnap allows teams to devote their energy to scientific progress and faster iteration. Security and data protection remain foundational principles, with clear safeguards outlined in our Terms of Use and Privacy Policy to ensure your work stays protected.
Advancing Discovery with Immune Builder on Neurosnap
Using Immune Builder on Neurosnap could drastically accelerate immune-protein structure prediction for antibodies, nanobodies, and TCRs with residue-level error review.
- Immune-format inputs: Immune Builder accepts antibody, nanobody, and TCR sequence layouts directly, without forcing them into a generic folding interface.
- Specialized model family: AbodyBuilder2, NanoBodyBuilder2, and TCRBuilder2 are tuned for the immune architectures researchers actually work with.
- Scientist-friendly interpretation: Residue-level predicted error helps users judge uncertain loops and chain interfaces before downstream use.
- Fast structural triage: The workflow is well suited to rapid candidate review during discovery, humanization, or repertoire-analysis campaigns.
How to Use Immune Builder on Neurosnap
To harness the capabilities of Immune Builder, researchers can follow this streamlined workflow within Neurosnap:
- Access Neurosnap: Start by logging in to the Neurosnap website.
- Select Tool: From the list of available tools, choose Immune Builder.
- Provide Inputs: Provide all the inputs specified within the submission panel and optionally configure the tool as desired.
- Run Tool: Submit the Immune Builder job and Neurosnap will execute it in the cloud, automatically notifying you as soon as your results are ready.
- Review Output: Explore your results through rich visualizations, including figures, plots, and interactive views designed to help you analyze findings with clarity and confidence.
Similar Services
Explore related tools that support similar research workflows:
Proudly supporting 50,000+ scientists worldwide, including 7,000+ leading biotech and global biopharma organizations.
Making Scientific Research
Faster & Easier
Register for free — upgrade anytime.
Interested in getting a license? Contact Sales.
Try Free