PLACER
Confidence-ranked ligand and protein side-chain ensembles.
Overview
PLACER generates local protein–ligand conformational ensembles with an atomistic denoising network. Sample ligand poses and nearby side chains, or explore an apo protein pocket around a selected residue. Ligands must already be present in the input complex.
Run PLACER on Neurosnap
The PLACER online webserver allows anybody with a Neurosnap account to run and access PLACER, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong Terms of Use and Privacy Policy.
Features
- Sample ligand poses and nearby protein side chains in a local pocket.
- Explore apo side-chain ensembles around a target residue.
- Predict multiple ligands together or keep selected cofactors fixed.
- Rank samples by predicted positional uncertainty or lDDT confidence.
Statistics
Neurosnap periodically calculates runtime statistics based on job execution data. These estimates provide a general guideline for how long your job may take, but actual runtimes can vary significantly depending on factors like input size or settings used.
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API Request
Access PLACER using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.
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Citations
Please cite the original work when using PLACER in publications or research outputs.
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PLACER: Protein-Ligand Atomistic Conformational Ensemble Resolver. https://doi.org/10.1101/2024.09.25.614868 |
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Neurosnap Inc. (2022). Neurosnap: An online platform for computational biology and chemistry. Available at: https://neurosnap.ai/ |