Use USalign Structural Alignment

Official Neurosnap webserver for accessing USalign Structural Alignment online.

Overview

US-align is a unified tool for comparing 3D structures of proteins, RNAs, and DNAs across various configurations (monomers, oligomers, and heterocomplexes) for pairwise and multiple alignments. It builds on TM-align, optimizing structural alignment through heuristic dynamic programming to maximize TM-score. Benchmark tests show that US-align achieves high accuracy with reduced CPU time compared to specialized alignment methods.

Neurosnap Overview

The USalign Structural Alignment online webserver allows anybody with a Neurosnap account to run and access USalign Structural Alignment, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong Terms of Use and Privacy Policy.

Features

  • Performs 3D structure alignments for monomeric and complex structures of proteins, RNAs, and DNAs.
  • Utilizes a unified TM-score objective function for improved alignment accuracy and speed.
  • Optimized for fast and accurate alignment of complex oligomers and large macromolecular structures.
  • Includes a heuristic iterative searching algorithm to avoid local minima in alignments.

Statistics

Neurosnap periodically calculates runtime statistics based on job execution data. These estimates provide a general guideline for how long your job may take, but actual runtimes can vary significantly depending on factors like input size or settings used.

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API Request

Access USalign Structural Alignment using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.

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