Use RoseTTAFold3
Official Neurosnap webserver for accessing RoseTTAFold3 online.
Overview
RosettaFold-3 (RF3) is a unified biomolecular foundation model developed using the AtomWorks framework. It is designed to bridge the gap between open-source models and AlphaFold 3, offering state-of-the-art accuracy in predicting arbitrary biomolecular complexes, including proteins, nucleic acids, small molecules, and mixed L/D peptides. RF3 distinguishes itself with improved handling of chirality through geometric conditioning and the ability to accept arbitrary atom-level constraints for tasks like docking and conformer templating.
Neurosnap Overview
The RoseTTAFold3 online webserver allows anybody with a Neurosnap account to run and access RoseTTAFold3, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong terms of service and privacy policy.
View PaperFeatures
- Built on AtomWorks, a modular framework for rapid prototyping and high-quality data processing.
- Explicit geometric features for chirality ensure 88% accuracy on ligand chiral centers.
- Arbitrary atom-level conditioning allows user-specified distance constraints and ligand conformers.
- Unified architecture capable of structure prediction, generative design, and fixed-backbone design.
- Trained on novel distillation datasets for nucleic acids, RNA, and disordered protein regions.
- Demonstrates high accuracy on mixed L/D peptides and antibody-antigen complexes.
- Performance competitive with AlphaFold 3 and exceeding Boltz-1/Boltz-2 on multiple benchmarks.
Statistics
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API Request
Access RoseTTAFold3 using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.
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