Use RFdiffusion3
Official Neurosnap webserver for accessing RFdiffusion3 online.
Overview
RFdiffusion3 (RFD3) is a fully atom-based diffusion model that generates protein structures—including explicit side chains—in the context of nucleic acids, small molecules, and other non-protein atoms. By modeling all polymer atoms explicitly, RFD3 enables precise conditioning on complex atom-level constraints, such as hydrogen bond donor/acceptor status and solvent accessibility. The model utilizes a streamlined architecture to achieve state-of-the-art performance on protein, ligand, and DNA binder design benchmarks while operating at approximately one-tenth the computational cost of RFdiffusion2.
Neurosnap Overview
The RFdiffusion3 online webserver allows anybody with a Neurosnap account to run and access RFdiffusion3, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong Terms of Use and Privacy Policy.
Features
- Fully atomistic generation creates protein backbones and side chains simultaneously, enabling precise modeling of interactions.
- Advanced atom-level conditioning allows direct control over hydrogen bonding, solvent accessibility (RASA), and center-of-mass positioning.
- Streamlined architecture (approx. 168M parameters) delivers a 10-fold speed increase over RFdiffusion2 without sacrificing performance.
- Demonstrated success in designing high-affinity binders, symmetric oligomers, and enzymes with complex active site scaffolding.
Statistics
Neurosnap periodically calculates runtime statistics based on job execution data. These estimates provide a general guideline for how long your job may take, but actual runtimes can vary significantly depending on factors like input size or settings used.
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API Request
Access RFdiffusion3 using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.
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