Use RFdiffusion2
Official Neurosnap webserver for accessing RFdiffusion2 online.
Overview
RFdiffusion2 is a deep generative method that enables the design of enzymes directly from sequence-agnostic, atom-level descriptions of their active sites (theozymes). It overcomes previous limitations by simultaneously inferring appropriate side-chain rotamers and sequence positions for catalytic residues, eliminating the need for computationally intensive enumeration steps.
Neurosnap Overview
The RFdiffusion2 online webserver allows anybody with a Neurosnap account to run and access RFdiffusion2, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong Terms of Use and Privacy Policy.
Features
- Atom-level active site scaffolding
- Unindexed (sequence-agnostic) motif scaffolding
- Simultaneous rotamer and scaffold inference
- Conditioning on ligand functional groups
- Generation of full ligand conformers from partial structures
Statistics
Neurosnap periodically calculates runtime statistics based on job execution data. These estimates provide a general guideline for how long your job may take, but actual runtimes can vary significantly depending on factors like input size or settings used.
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API Request
Access RFdiffusion2 using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.
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Job Note
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Inputs & Configuration
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