Use OpenFold3 (AlphaFold3)

Overview

OpenFold3 (OF3) is an open-source, bitwise reproduction of AlphaFold3 that delivers near-parity performance for comprehensive biomolecular structure prediction across proteins, nucleic acids, and protein–ligand complexes. Developed by a consortium including Columbia University, Lawrence Livermore National Laboratory, Novo Nordisk, AWS, Seoul National University, the Chan Zuckerberg Initiative, Absci, SandboxAQ, NVIDIA, and others, OF3 replicates the diffusion-based multimodal architecture of AlphaFold3 while incorporating stability and correctness improvements. Key refinements include updated LayerNorm handling, corrected inter-chain masking logic, revised distance binning, and updated sequence and structure databases. Benchmarks across CASP16, FoldBench, and Runs N’ Poses demonstrate performance within experimental error of AlphaFold3 on RNA and monomeric proteins, and competitive results on multimeric and ligand-bound complexes. OpenFold3 is fully open-source with inference and training code, model weights, and documentation to support community-driven research in structural biology and drug discovery.

Neurosnap Overview

The OpenFold3 (AlphaFold3) online webserver allows anybody with a Neurosnap account to run and access OpenFold3 (AlphaFold3), no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong terms of service and privacy policy.