Use NeuroBind

Official Neurosnap webserver for accessing NeuroBind online.

Protein Design Antibody Design Drug Design Molecular Dynamics

Overview

The most advanced tool for designing high-affinity binders like antibodies, nanobodies, scFvs, and peptides against any target. NeuroBind combines AI, physics, and evolutionary principles for best-in-class performance.

Neurosnap Overview

The NeuroBind online webserver allows anybody with a Neurosnap account to run and access NeuroBind, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong terms of service and privacy policy.

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Features

  • Supports the design of antibodies, nanobodies, scFvs, and peptides against arbitrary protein or complex targets.
  • Automatically performs in silico affinity maturation, achieving predicted affinities in the -15 to -20 kcal/mol range.
  • Allows programmable design for properties such as high solubility, low immunogenicity, and enhanced thermal/solvent stability.
  • Employs a hybrid AI framework combining deep learning with evolutionary constraints and physics-based simulations.
  • Outperforms pure ML-based approaches in both predicted binding affinity and developability.
  • Produces diverse candidate binders that adhere to biologically realistic structural and functional constraints.

Statistics

Neurosnap periodically calculates runtime statistics based on job execution data. These estimates provide a general guideline for how long your job may take, but actual runtimes can vary significantly depending on factors like input size or settings used.

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API Request

Access NeuroBind using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.

Job Note

Provide a name or description for your job to help you organize and track its results. This input is solely for organizational purposes and does not impact the outcome of the job.

Configuration & Options

Important Information

NeuroBind is a compute-intensive model. Typical runtimes average around 12 hours, but larger or more complex targets may require multiple days to complete.

Service Inputs

Amino acid sequences of the molecules you wish to target. NeuroBind will automatically design a binder against the provided sequence(s). If multiple sequences are entered, a binder will be designed against the full target complex.

Select the type of binder to design. Available options include "Antibody", "Nanobody", "scFv", and "Peptide".

Specify the amino acid length of the binder. Only available for when "Design Mode" is set to "Peptide".

Hotspots (Optional)

Hotspots allow you to guide NeuroBind to focus binding interactions on specific regions of your target. These are typically known or desired binding sites—such as epitopes or functional surfaces—that you want the designed binder to interact with. In the context of antibody design, hotspots can be thought of as the ideal epitope region within the target.

Each hotspot is defined on a separate line using the following format:

SEQ_ID:RES_ID
  • SEQ_ID → The name of the target sequence containing the hotspot.
  • RES_ID → The residue index (1-based) within that sequence.


🔹 Example Input:

Protein_1:6
Protein_1:7
Protein_2:26
Protein_2:28


⚠️ Notes:

  • Sequence names must match those provided in Target Sequences.
  • Residue indices are 1-based (i.e., the first residue is 1, not 0).
  • You can provide one or more hotspots depending on your design goals.

Specify binding hotspots. See above instructions for more details.

Ready to submit your job?

Once you're done just hit the submit button below and let us do the rest.

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