Use ImaPEp Antibody-Antigen Binding Prediction

Official Neurosnap webserver for accessing ImaPEp Antibody-Antigen Binding Prediction online.

BETA - MAY CONTAIN BUGS Drug Discovery Antibodies

Overview

ImaPEp is a computational tool designed for predicting the binding probability of paratope–epitope pairs in antibody-antigen complexes. Utilizing a novel image-based approach, ImaPEp simplifies 3D structural data into 2D representations of binding interfaces and employs convolutional neural networks to analyze these interactions. By incorporating physicochemical properties and spatial compatibility, ImaPEp achieves high accuracy in identifying binding pairs and offers valuable insights into antibody design. Its efficiency and scalability make it ideal for applications such as docking pose rescoring, high-throughput screening of paratope libraries, and refining antibody-antigen complex structures, thereby accelerating advancements in immunotherapy and biomedical research.

Neurosnap Overview

The ImaPEp Antibody-Antigen Binding Prediction online webserver allows anybody with a Neurosnap account to run and access ImaPEp Antibody-Antigen Binding Prediction, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong terms of service and privacy policy.

View Paper

Features

  • Predicts paratope–epitope binding pairs with high accuracy, achieving a balanced accuracy (BAC) of 0.84 and AUROC of 0.94.
  • Introduces a novel 2D image-based approach for antibody–antigen interfaces, leveraging physicochemical properties and spatial compatibility.
  • Provides a detailed report, including the number and type of intermolecular contacts, percentage of charged and polar residues, and residue-specific interactions.

Statistics

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API Request

Access ImaPEp Antibody-Antigen Binding Prediction using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.

Job Note

Provide a name or description for your job to help you organize and track its results. This input is solely for organizational purposes and does not impact the outcome of the job.

Configuration & Options

Service Inputs

The input PDB to analyze.

Provide the chain identifier for antibody heavy chain.

Provide the chain identifier for antibody light chain.

Provide the chain identifier(s) for the antigen. Note: The antigen must be a protein containing at least 50 residues, and its chain identifiers should be specified as a continuous sequence of letters (e.g., ABCD). Each letter represents a unique chain in the protein structure. For example, if the antigen comprises four chains labeled A, B, C, and D in the PDB file, these should be listed consecutively without spaces or punctuation as ABCD.

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