Use Humatch

Official Neurosnap webserver for accessing Humatch online.

Antibodies Protein Design

Overview

Humatch is a fast, gene-specific tool designed to jointly humanize antibody heavy and light chains. Leveraging lightweight convolutional neural networks (CNNs), Humatch classifies human antibody sequences with near-perfect accuracy and guides the humanization process by aligning sequences with specific human germline V-genes. It ensures optimal VH/VL pairing to maintain stability and expression while reducing immunogenicity risks. Additionally, Humatch provides robust classification of antibody sequences, distinguishing between human and non-human origins with high precision.

Neurosnap Overview

The Humatch online webserver allows anybody with a Neurosnap account to run and access Humatch, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong terms of service and privacy policy.

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Features

  • Jointly humanizes antibody heavy (VH) and light (VL) chains for better pairing and stability.
  • Ensures alignment with specific human germline V-genes, avoiding hybrid gene designs.
  • Reduces immunogenicity risks while maintaining expression and binding efficiency.

Statistics

Neurosnap periodically calculates runtime statistics based on job execution data. These estimates provide a general guideline for how long your job may take, but actual runtimes can vary significantly depending on factors like input size or settings used.

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API Request

Access Humatch using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.

Job Note

Provide a name or description for your job to help you organize and track its results. This input is solely for organizational purposes and does not impact the outcome of the job.

Configuration & Options

Service Inputs

Choose the mode for prediction. Classification predicts and classifies antibody sequences as human or non-human. Humanising optimizes sequences for human compatibility and reduced immunogenicity.

Provide the amino acid sequence of the antibody you wish to analyze in the following format: "heavy chain:light chain". The sequence must always start with the heavy chain, followed by a colon (:), and then the light chain. Note: Humatch was trained exclusively on complete VH (variable heavy) and VL (variable light) chain sequences. Therefore, only complete sequences in the correct order should be submitted as input.

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