Use EvoEF2 Mutant Stability Analysis

Official Neurosnap webserver for accessing EvoEF2 Mutant Stability Analysis online.

Protein Design

Overview

Performs mutant stability analysis using the EvoEF2 energy function. Upload a wild-type protein structure and define one or more mutant variants. EvoEF2 will generate mutant models, calculate their stability scores, and compare them to the wild-type structure.

Neurosnap Overview

The EvoEF2 Mutant Stability Analysis online webserver allows anybody with a Neurosnap account to run and access EvoEF2 Mutant Stability Analysis, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong terms of service and privacy policy.

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Features

  • Analyzes the impact of specified mutations on protein stability.
  • Computes detailed stability scores for wild-type and mutant structures using EvoEF2.
  • Supports definition of multiple mutations per variant.
  • Allows analysis of multiple mutant variants.
  • Automatically generates mutant PDB models based on definitions.

Statistics

Neurosnap periodically calculates runtime statistics based on job execution data. These estimates provide a general guideline for how long your job may take, but actual runtimes can vary significantly depending on factors like input size or settings used.

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API Request

Access EvoEF2 Mutant Stability Analysis using the Neurosnap API by sending a request using any programming language with HTTP support. To safely generate an API key, visit the API tab of your overview page.

Job Note

Provide a name or description for your job to help you organize and track its results. This input is solely for organizational purposes and does not impact the outcome of the job.

Configuration & Options

Service Inputs

Upload the wild-type protein PDB file. Mutations specified in the Mutant Definitions field will be applied to this structure, and their effect on stability will be analyzed.

Input mutations to apply to the wild-type structure. Each line defines a separate mutant variant. Format for a single mutation: <WildTypeAA><ChainID><Position><MutantAA> (e.g., TA159M where 'T' is wild-type amino acid, 'A' is Chain ID, '159' is position, 'M' is Mutant amino acid). For variants with multiple mutations, list them comma-separated on the same line (e.g., TA159M,DA166V). Ensure residue positions and wild-type amino acids match the input wild-type PDB structure.

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