Use Conformer Generator

The input small molecule you want to create conformers for.

The initial number of random conformers to generate. These conformers will be filtered and the number that will be returned will be less

A minimization step is conducted to minimize free energy to filter out energetically unfavorable conformers. The UFF force field is suitable for a broad range of molecules, including organics, inorganics, and organometallics. It is fast and provides reasonable geometries. MMFF94 is more accurate for organic molecules, especially when dealing with pharmaceuticals. It is recommended for more precise calculations but is slightly slower than UFF. While MMFF94 is already quite accurate, using the "MMFF94s" variant can provide even more accurate energy minimization, particularly for systems that include steric effects like lone pairs or pi-pi interactions. Some experiments and most theoretical calculations show significant pyramidal “puckering” at nitrogens in isolated structures. The MMFF94s (static) variant has slightly different out-of-plane bending and dihedral torsion parameters to planarize certain types of delocalized trigonal N atoms, such as aromatic aniline. This provides a better match to the time-average molecular geometry in solution or crystal structures. If you are comparing force-field optimized molecules to crystal structure geometries, we recommend using the MMFF94s variant for this reason. All other parameters are identical. However, if you are perfoming “docking” simulations, consideration of active solution conformations, or other types of computational studies, we recommend using the MMFF94 variant, since one form or another of the N geometry will predominate. Finally, the newer "auto" option will cycle through various force-field options starting with MMFF94 until a method succeeds.