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BETA - MAY CONTAIN BUGS Protein Folding Molecular Docking

Overview

CombFold predicts the structures of large protein complexes from subunit sequences using AlphaFold Multimer paired with a cominatorial method to assemble subunits.

Neurosnap Overview

The CombFold online webserver allows anybody with a Neurosnap account to run and access CombFold, no downloads required. Information submitted through this webserver is kept confidential and never sold to third parties as detailed by our strong terms of service and privacy policy.

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Features

  • This is a beta service. Be advised that you may encounter issues that currently have no solutions.
  • Deploys a Combinatorial Assembly algorithm to assemble subcomplexes into large structures.
  • CombFold uses AlphaFold Multimer to predict subcomplexes of a target complex.

Configuration & Options

Model Input

Each entry in this fasta input corresponds to a subunit of the complex you are trying to predict the structure of. Subunits can be either be a single sequence or multiple sequences. For multiple sequences, delimit chains using the ":" character. Note that each subunit name / fasta header must end with "_#chains" For example if I have a subunit which is a homo-hexamer then the name of that subunit must be ">name_a_6".

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